Development of a behavioural intervention for cognitive fatigability in multiple sclerosis: Protocol for a pilot and...

Area of Science:

• Neurology
• Rehabilitation Science
• Behavioral Medicine

Background:

• Fatigue is a primary symptom for up to 90% of people with multiple sclerosis (PwMS).
• Cognitive fatigability (CF), a decline in performance after sustained cognitive effort, is a key component of fatigue in MS.
• There is a significant need for interventions specifically targeting CF in PwMS.

Purpose of the Study:

• To develop and pilot a multi-dimensional behavioral intervention to improve cognitive fatigability in PwMS.
• To assess the feasibility and potential efficacy of a group-based, videoconference-delivered program.
• To gather participant input to refine the intervention for future randomized controlled trials.

Main Methods:

• A multi-stage approach including intervention development, needs assessment via survey (n=100 PwMS), and a pilot feasibility study (n=20 PwMS).
• The intervention consists of 8 weekly 70-minute videoconference group sessions focusing on body, mood, mind, and context.
• Data collection includes baseline and follow-up assessments to evaluate CF and feasibility outcomes.

Main Results:

• The study protocol is designed to yield preliminary data on the feasibility of the intervention.
• Primary outcome will be improvement in cognitive fatigability.
• Feasibility outcomes will guide the design of a future randomized controlled trial.

Conclusions:

• This pilot study protocol aims to establish an effective, accessible behavioral intervention for cognitive fatigability in PwMS.
• The long-term goal is to improve quality of life and cognitive function in daily activities for PwMS.
• Refinement based on participant feedback will inform the optimal design for larger trials.