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Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Michaël Mekeirele1, Silke Verheyen2, Ruth Van Lancker1

  • 1aDepartment of Intensive Care Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussel, Belgium.

Case Reports in Nephrology and Dialysis
|December 15, 2022
PubMed

Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.

Keywords:
BenzodiazepineBlood purificationBromazepamHemadsorptionIntoxication

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