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Recent advances in regenerative biomaterials.

Dinglingge Cao1, Jiandong Ding1

  • 1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Regenerative Biomaterials
|December 15, 2022
PubMed
Summary

Regenerative biomaterials are advancing beyond inert supports to bioactive materials that promote tissue regeneration. This review covers recent progress in various materials and applications, including bone, cartilage, cardiovascular repair, and public health emergencies.

Keywords:
medical materialregenerative biomaterialtissue induction biomaterialtissue regeneration

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Biomaterials have evolved from inert supports to bioactive agents promoting tissue regeneration.
  • The concept of regenerative biomaterials extends beyond tissue induction, encompassing a broader range of applications.
  • Interdisciplinary advancements have redefined biomaterials, emphasizing their role in stimulating inherent healing capabilities.

Purpose of the Study:

  • To review recent progress in regenerative biomaterials.
  • To highlight applications in bone, cartilage, cardiovascular repair, 3D bioprinting, wound healing, and medical cosmetology.
  • To discuss the impact of biomaterials on public health emergencies, particularly coronavirus disease 2019.

Main Methods:

  • Comprehensive literature review of recent advancements in biomaterials.
  • Categorization of materials including metals, ceramics, hydrogels, polymers, and bio-derived substances.
  • Analysis of cell-biomaterial interactions and their significance in regenerative processes.

Main Results:

  • Regenerative biomaterials show promise across diverse applications, from tissue repair to medical cosmetology.
  • Recent developments focus on enhancing bioactivity and understanding cell-material interactions.
  • The review highlights the critical role of biomaterials in addressing public health emergencies.

Conclusions:

  • Future directions include developing novel materials, optimizing existing ones, and ensuring harmonious degradation and regeneration.
  • Monitoring *in vivo* dynamics noninvasively and focusing on long-term outcomes are crucial.
  • Accelerating clinical translation and continued research are essential for advancing regenerative biomaterials.