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Leukocytosis and MPNs: Where do we stand?
1Department of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA.
Leukemia & Lymphoma
|December 15, 2022
Summary
Leukocytosis is common in Philadelphia-negative myeloproliferative neoplasms (MPNs) but its impact on thrombosis, fibrosis, and leukemia risk remains unclear. Further research is needed to clarify its role in MPN prognostication.
Area of Science:
- Hematology
- Oncology
Background:
- Philadelphia-negative myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are associated with thrombotic events and transformation risks.
- Leukocytosis is a diagnostic criterion for MF and is observed in many MPN patients.
Purpose of the Study:
- To review and analyze published investigations on the impact of leukocytosis in MPNs.
- To explore the evolving role of leukocytosis in disease prognostication within the context of molecular and genetic studies.
Main Methods:
- Review of multiple large retrospective and prospective studies.
- Analysis of existing literature on leukocytosis in MPNs.
Main Results:
- The association between leukocytosis and thrombosis, fibrosis, and leukemic transformation in MPNs is not definitively established.
- Leukocytosis is a recognized factor in MPN diagnosis and patient populations.
Conclusions:
- The precise impact of leukocytosis on MPN outcomes requires further elucidation.
- The prognostic significance of leukocytosis is being re-evaluated alongside advancements in molecular and genetic profiling of MPNs.
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