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Leukocytosis and MPNs: Where do we stand?

Alexander Coltoff1

  • 1Department of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA.

Leukemia & Lymphoma
|December 15, 2022
PubMed

Insights

Leukocytosis is common in Philadelphia-negative myeloproliferative neoplasms (MPNs) but its impact on thrombosis, fibrosis, and leukemia risk remains unclear. Further research is needed to clarify its role in MPN prognostication.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Philadelphia-negative myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are associated with thrombotic events and transformation risks.
  • Leukocytosis is a diagnostic criterion for MF and is observed in many MPN patients.

Purpose of the Study:

  • To review and analyze published investigations on the impact of leukocytosis in MPNs.
  • To explore the evolving role of leukocytosis in disease prognostication within the context of molecular and genetic studies.

Main Methods:

  • Review of multiple large retrospective and prospective studies.
  • Analysis of existing literature on leukocytosis in MPNs.

Main Results:

  • The association between leukocytosis and thrombosis, fibrosis, and leukemic transformation in MPNs is not definitively established.
  • Leukocytosis is a recognized factor in MPN diagnosis and patient populations.

Conclusions:

  • The precise impact of leukocytosis on MPN outcomes requires further elucidation.
  • The prognostic significance of leukocytosis is being re-evaluated alongside advancements in molecular and genetic profiling of MPNs.
Keywords:
Myeloproliferative disordersmyeloid leukemias and dysplasiasprognostication

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