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Understanding the Complex Interactions between Coffee, Tea Intake and Neurologically Relevant Tissues Proteins in the
1Feng Zhang, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China 710061,
The Journal of Nutrition, Health & Aging
|December 15, 2022
Summary
This study found that specific proteins in the brain and blood are linked to how coffee and tea intake affect anxiety and depression. These protein interactions offer new insights into the causes of these mental health conditions.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Coffee and tea consumption are common globally.
- Their association with psychiatric diseases like anxiety and depression is suspected but not fully understood.
- The role of specific proteins in these associations remains unclear.
Purpose of the Study:
- To investigate the interaction between coffee/tea intake and protein polygenic risk scores (PRS).
- To examine the effect of these interactions on the risks of anxiety and depression.
- To identify specific proteins that may mediate the relationship between beverage intake and mental health outcomes.
Main Methods:
- Cross-sectional study utilizing UK Biobank data for coffee and tea intake.
- Genome-wide association study (GWAS) data for 1,537 proteins from neurologically relevant tissues.
- Multivariate linear analysis to assess interaction effects between beverage intake, protein PRS, and psychiatric conditions, controlling for covariates.
Main Results:
- Significant interactions were found between coffee intake and proteins (e.g., c-Jun, Fas) for anxiety.
- Significant interactions were observed between tea intake and proteins (e.g., sL-Selectin, IL-1F6) for anxiety.
- Interactions between coffee intake (e.g., IL-1 sRI, NXPH1) and tea intake (e.g., COLEC12, Layilin) with proteins were also significant for depression.
Conclusions:
- Multiple proteins in neurologically relevant tissues play a role in the association between coffee/tea intake and psychiatric diseases.
- These findings provide potential targets for understanding the mechanisms of anxiety and depression.
- Further research can explore these protein-mediated pathways to develop novel interventions.
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