Malnutrition Increases the Risk of Left Ventricular Remodeling
1Nianjin Xie, MD; Yong Liu, MD, PhD, FACC; Jin Liu, MD, Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China, Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong, Academy of Medical Sciences, Guangzhou, 510080, China, Tel: (+86) 02083827812-10528/Fax: (+86) 02083851483, E-mail: xnj-nm@163.com; liuyong@gdph.org.cn; ljaw397017568@163.com.
The Journal of Nutrition, Health & Aging
|December 15, 2022
Summary
Moderate-to-severe malnutrition significantly increases the risk of left ventricular (LV) remodeling in heart failure patients. This study highlights the importance of nutritional status in predicting adverse cardiac events and LV remodeling.
Area of Science:
- Cardiology
- Nutritional Science
Background:
- Malnutrition is linked to a higher incidence of heart failure (HF).
- Left ventricular (LV) remodeling is a critical process in HF development and progression.
- The relationship between nutritional status and LV remodeling remains unclear.
Purpose of the Study:
- To investigate the association between malnutrition and LV remodeling in patients.
- To determine if nutritional status predicts the risk of LV remodeling.
Main Methods:
- A retrospective observational study included 7,217 patients from a hospital registry (2007-2018).
- Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score, categorizing patients into absent-mild (≤4) and moderate-severe (>4) malnutrition groups.
- LV remodeling was defined as a ≥10% decrease in LV ejection fraction post-discharge. Associations were analyzed using logistic regression.
Main Results:
- 9.9% of patients (712) experienced LV remodeling.
- The moderate-severe malnutrition group had a significantly higher incidence of LV remodeling (12.9% vs. 9.5%, p=0.002).
- Moderate-severe malnutrition was independently associated with a 1.69-fold increased risk of LV remodeling (OR: 1.69, CI: 1.32-2.16).
Conclusions:
- Moderate-to-severe malnutrition is a significant risk factor for LV remodeling in heart failure patients.
- Approximately 12% of patients with moderate-severe malnutrition developed LV remodeling.
- Further prospective studies are warranted to explore nutrition-focused interventions for patients with LV remodeling.
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