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Emergent roles of maternal microchimerism in postnatal development

Alexandria Borges1, Flore Castellan1, Naoki Irie1

  • 1Graduate School of Science, Department of Biological Sciences, The University of Tokyo, Tokyo, Japan.

Development, Growth & Differentiation
|December 15, 2022
PubMed

Maternal microchimerism (MMc) is the phenomenon that a low number of cells from the mother persists within her progeny. Despite their regular presence in mammalian pregnancies, the overall cell type repertoire and roles of maternal cells, especially after birth, remain unclear. By using transgenic mouse strains and human umbilical blood samples, recent studies have for the first time characterized and quantified MMc cell type repertoires in offspring, identified the cross-generational influence on fetal immunity, and determined possible factors that affect their presence in offspring. This review summarizes new findings, especially on the maternal cell type repertoires and their potential role in utero, in postnatal life, and long after birth.

Keywords:
cell-level epigeneticsimmune developmentmaternal microchimerism

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