Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

33.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
33.5K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

67
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
67
Overview of Cell Signaling01:23

Overview of Cell Signaling

20.7K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
20.7K
What is Cell Signaling?02:03

What is Cell Signaling?

119.8K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
119.8K
Types of Signaling Molecules01:32

Types of Signaling Molecules

10.5K
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
10.5K
Yeast Signaling01:28

Yeast Signaling

14.7K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Engineering a Transmembrane Receptor for Coacervate-Based Artificial Cells.

Journal of the American Chemical Society·2026
Same author

Harnessing pre-existing measles immunity: mRNA-Lipid nanoparticle-mediated measles hemagglutinin expression boosts antitumor CD8⁺ T cell responses.

Signal transduction and targeted therapy·2026
Same author

Converging frontiers in biomolecular condensate and synthetic cell research.

npj biomedical innovations·2026
Same author

Bio-Propelled Stomatocyte Nanomotors with Glutathione-Responsiveness for Osteoarthritis Treatment.

Angewandte Chemie (International ed. in English)·2026
Same author

A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker.

MicrobiologyOpen·2026

Related Experiment Video

Updated: Aug 17, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.6K

Quorum sensing communication between lipid-based artificial cells.

Antoni Llopis-Lorente1,2, Bastiaan C Buddingh'1, R Martínez-Máñez2

  • 1Department of Chemical Engineering and Chemistry, Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Het Kranenveld 14, 5600 MB, Eindhoven, The Netherlands. J.C.M.v.Hest@tue.nl.

Chemical Communications (Cambridge, England)
|December 15, 2022
PubMed
Summary

Researchers created artificial cells that exhibit quorum sensing, a communication behavior found in microorganisms. This artificial system mimics natural cell-to-cell communication, allowing study of factors influencing collective behavior.

More Related Videos

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer
09:37

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

11.2K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K

Related Experiment Videos

Last Updated: Aug 17, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.6K
Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer
09:37

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

11.2K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.0K

Area of Science:

  • Synthetic Biology
  • Biochemistry
  • Microbiology

Background:

  • Microbial population behavior is often governed by quorum sensing, a cell-density-dependent communication mechanism.
  • Understanding quorum sensing in artificial systems can provide insights into biological communication.

Purpose of the Study:

  • To demonstrate quorum sensing behavior in an artificial cell population.
  • To investigate the influence of cell density, fuel concentration, and proximity on artificial quorum sensing.

Main Methods:

  • Constructed artificial cells using giant lipid vesicles.
  • Encapsulated sender-receiver molecular machinery within the vesicles.
  • Analyzed collective output in relation to varying environmental factors.

Main Results:

  • Successfully induced quorum sensing behavior in the artificial cell population.
  • Demonstrated that collective output is dependent on cell density, fuel concentration, and vesicle proximity.
  • Established a model system for studying quorum sensing dynamics.

Conclusions:

  • Artificial cells can effectively recapitulate complex population behaviors like quorum sensing.
  • The developed system provides a controllable platform for exploring quorum sensing mechanisms.
  • This work bridges synthetic biology and fundamental studies of microbial communication.