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Updated: Aug 6, 2026

Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
An era of therapeutic translation
1Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, New York, NY 10029.
Abstract:
Diagnostic advances currently have exceeded therapeutic gain. The present, however, is a transition phase. Chemotherapy, for example, has become curative for some tumors in recent years, rather than merely palliative, due to the precision permitted by advances in molecular biology. At this time, acceleration in the basic oncologic sciences has surpassed therapeutic advance, but therapeutic translation has begun and we will require clinical scientists to increase the bridge from laboratory to bedside if we are to speed the contribution of the so-called biologic revolution to cancer control.
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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