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Specification of Hsp70 Function by Hsp40 Co-chaperones

Douglas M Cyr1, Carlos H Ramos2

  • 1Department of Cell Biology and Physiology, School of Medicine University of North Carolina, Chapel Hill, NC, USA. dmcyr@med.unc.edu.

Sub-Cellular Biochemistry
|December 15, 2022
PubMed
Summary

Molecular chaperones, including Heat Shock Protein 70 (Hsp70) and its co-chaperones Heat Shock Protein 40 (Hsp40), maintain cellular proteostasis. This review details how Hsp40s direct Hsp70 clients toward protein folding or degradation pathways.

Keywords:
Hsp40Hsp70Molecular chaperoneProtein foldingProtein triage

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