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Updated: Aug 17, 2025
Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56bright NK Cells via Stimulation of
Michael ToVinh1,2, Gregor Hörr1,2, Christoph Hoffmeister1,2
1Department of Internal Medicine I, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
Abstract:
The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-γ production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-β production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.
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