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Updated: Aug 17, 2025
A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Evaluation of Triclosan coated suture in obstetrical surgery: A prospective randomized controlled study (NCT05330650)
Wael Mbarki1,2, Hajer Bettaieb1,2, Nesrine Souayeh1,2
1Department of Gynecology and Obstetrics, Ben Arous Hospital, Ben Arous, Tunisia.
Objectives:
To assess the effectiveness of Triclosan coated suture in reducing surgical site infections (SSIs) rate after caesarian delivery (CD).
Study Design:
Three hundred eighty patients were randomly assigned to closure with polyglactin non coated suture VICRYL, or with polyglactin coated suture VICRYL Plus after caesarian section. The primary outcome was the rate of SSIs within 30 days after surgery and secondary outcomes were the rate of wound healing complications.
Results:
SSI rate was 2.5% in Triclosan group compared to 8.1% with non-coated suture. Use of Triclosan coated suture (TCS) was associated with 69% reduction in SSI rate (p = 0.037; ORa:0.294; 95% CI:0.094-0.921). The use of Triclosan coated suture was associated with statistically lower risk of wound oedema (2.5% vs 10%), (p = 0.019; OR:0.595), dehiscence (3.8% vs 10.6%), (p = 0.023; OR:0.316) and hematoma (p = 0.035; OR:0.423).
Conclusion:
Our results confirm the effectiveness of Triclosan coated suture in reducing SSI rate and wound healing disturbances.
Trial Registration:
Registered at ClinicalTrials.gov / ID (NCT05330650).
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