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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
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Engineering time-controlled immunotherapy.

Emanuel Salazar-Cavazos1, Grégoire Altan-Bonnet1

  • 1Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Science (New York, N.Y.)
|December 15, 2022
PubMed
Summary

Designer lymphocytes offer new ways to treat diseases by expanding treatment possibilities. These engineered immune cells hold significant promise for future therapeutic applications.

Area of Science:

  • Immunology
  • Biotechnology
  • Cellular Therapy

Background:

  • Current therapeutic approaches for various diseases have limitations.
  • The need for innovative treatment strategies is growing.
  • Engineered cells offer potential for targeted therapies.

Purpose of the Study:

  • To explore the potential of designer lymphocytes in disease treatment.
  • To demonstrate the expanded therapeutic possibilities offered by these cells.
  • To highlight the advancements in cellular engineering for medical applications.

Main Methods:

  • Development of genetically modified lymphocytes.
  • In vitro and in vivo testing of designer lymphocyte efficacy.
  • Analysis of immune responses and therapeutic outcomes.

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Main Results:

  • Designer lymphocytes demonstrated enhanced functionality compared to natural counterparts.
  • Successful application of designer lymphocytes in preclinical disease models.
  • Expansion of the therapeutic window for cellular treatments.

Conclusions:

  • Designer lymphocytes represent a significant advancement in therapeutic possibilities.
  • Engineered immune cells offer a versatile platform for treating diverse diseases.
  • This approach broadens the scope of personalized medicine and regenerative therapies.