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Newly identified tumor suppressor functions of ING proteins

Léane Heliez1, Charles Ricordel2, Philippe Becuwe3

  • 1Univ Rennes 1, INSERM, OSS (Oncogenesis Stress Signaling), UMR_S 1242, CLCC Eugene Marquis, F-35000, Rennes, France.

Current Opinion in Pharmacology
|December 15, 2022
PubMed

Insights

The INhibitor of Growth (ING) proteins are key epigenetic regulators and tumor suppressors. New research reveals their expanded roles in metabolism and DNA repair, offering novel cancer treatment targets.

Area of Science:

  • Epigenetics and Molecular Biology
  • Cancer Research
  • Cellular Regulation

Background:

  • The INhibitor of Growth (ING) protein family (ING1-5) comprises epigenetic regulators.
  • ING proteins function as gatekeeper and caretaker tumor suppressors, regulating cell cycle, apoptosis, senescence, DNA replication, and DNA damage response (DDR).
  • Their reduced expression is observed in various cancers.

Purpose of the Study:

  • To review recent findings on ING protein interactions and functions.
  • To highlight novel antitumorigenic activities of ING proteins.
  • To identify potential new targets for cancer therapy.

Main Methods:

  • Literature review of recent studies on ING proteins.
  • Analysis of ING protein interactions with cellular pathways.
  • Examination of ING protein roles in gene expression and metabolism.

Main Results:

  • ING proteins interact with pathways regulating cell proliferation and stem cell pluripotency.
  • ING proteins are identified as regulators of ribosomal RNA synthesis, mRNA stability, and mitochondrial DNA transcription.
  • These functions contribute to the regulation of cellular metabolism.

Conclusions:

  • ING proteins possess newly identified antitumorigenic activities.
  • These expanded roles in metabolism and DNA regulation present novel therapeutic opportunities.
  • Targeting ING proteins could be a promising strategy for cancer treatment.

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