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Updated: Aug 17, 2025

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
Published on: September 28, 2018
Feasibility of intermediate theta burst stimulation as sham control in therapeutic transcranial magnetic stimulation
Kiran Bagali1, Vanteemar S Sreeraj1, Urvakhsh Meherwan Mehta1
1Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
Abstract:
A major challenge in Transcranial Magnetic Stimulation trials is that of an inefficient sham protocol. This could potentially amplify the gap in behavioral outcomes following true and control treatments. Intermediate theta-burst stimulation (imTBS) is a promising sham alternative since it uses actual TMS pulses, thus mimicking the sensory effects of stimulation without producing physiological aftereffects. Here, we critically review controlled experiments that have examined physiological and behavioral aftereffects following imTBS with the intention to further investigate what appears to be a promising sham control modality for TBS studies.
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