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Updated: Aug 17, 2025

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Published on: March 22, 2018
Primary and secondary olfactory centres in human ontogeny
A S Kharlamova1, O S Godovalova2, E G Otlyga1
1Avtsyn Research Institute of Human Morphology of FSBSI "Petrovsky National Research Centre of Surgery", Tsyurupy st., 3, 117418 Moscow, Russia.
This review details the normal development of human olfactory centers, crucial for understanding neurological disorders and olfaction changes. It clarifies terminology and maturation timelines for better research. Keywords: human olfaction, olfactory centers, neurological disorders, development.
Area of Science:
- Neuroscience
- Developmental Biology
- Histology
Background:
- Olfactory centers represent an evolutionarily ancient and conserved region of the telencephalon.
- Olfactory deficiencies are linked to various neurological and neurodegenerative diseases.
- Recent interest in human olfaction is amplified by COVID-19-related anosmia, yet normative histological and developmental data are scarce.
Purpose of the Study:
- To provide a comprehensive review of morphological data on the normal ontogeny of human olfactory centers.
- To focus on the developmental timetable and cytoarchitecture of these centers.
- To address inconsistencies in terminology and definitions of olfactory areas.
Main Methods:
- Review of existing literature on human olfactory center development.
- Analysis of morphological data focusing on prenatal and postnatal ontogeny.
- Comparison of human olfactory development with established animal models.
Main Results:
- Existing data on human olfactory center development are limited and often lack standardized nomenclature.
- The developmental timetable and cytoarchitecture are poorly understood and unsystematized.
- Discrepancies in terminology complicate the analysis of human olfactory research.
Conclusions:
- A standardized understanding of human olfactory center development is needed.
- This review aims to consolidate morphological data to establish a clear developmental timeline and cytoarchitecture.
- Clarifying terminology is essential for advancing research in human olfaction and related disorders.
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