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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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One-Year Risk of Myocarditis After COVID-19 Infection: A Systematic Review and Meta-analysis

Marco Zuin1, Gianluca Rigatelli2, Claudio Bilato3

  • 1Department of Cardiology, West Vicenza Hospital, Arzignano, Vicenza, Italy; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

The Canadian Journal of Cardiology
|December 15, 2022
PubMed

Insights

COVID-19 survivors face a significantly higher risk of developing myocarditis within a year post-infection. This systematic review highlights myocarditis as a rare but crucial post-acute COVID-19 complication.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Limited data exist on the risk of myocarditis in the post-acute phase of COVID-19.
  • Acute myocarditis is a recognized, though infrequent, cardiovascular complication of COVID-19.

Approach:

  • A systematic review and meta-analysis of studies published up to September 1, 2022, was conducted.
  • Data from 20,875,843 patients, including 1,245,167 COVID-19 survivors, were analyzed.
  • Mantel-Haenszel random-effects models were used to pool myocarditis risk data, calculating hazard ratios (HR) and 95% confidence intervals (CI).

Key Points:

  • COVID-19 survivors had a myocarditis incidence of 0.21 per 1000 patients versus 0.09 per 1000 in controls.
  • Recovered COVID-19 patients showed a 5.16-fold increased risk of incident myocarditis within one year (HR 5.16, 95% CI 3.87-6.89).
  • Sensitivity analyses confirmed these findings, indicating robust results.

Conclusions:

  • Myocarditis is a rare but significant sequela following COVID-19 infection.
  • The findings underscore the importance of monitoring for myocarditis in COVID-19 survivors.
Abstract

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