Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review

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Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
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Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

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Ann Bugeja1, Mariam Eldaba2, Sumaiya Ahmed2

  • 1Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada abugeja@toh.ca.

BMJ Open
|December 15, 2022
PubMed

Insights

This systematic review examines the safety of living kidney donation in individuals with hypertension. It aims to clarify risks to donor cardiovascular and kidney health, informing future clinical guidelines.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation Science

Background:

  • Historically, hypertension was a contraindication for living kidney donation.
  • Living kidney donation is crucial for managing kidney failure, leading to increased acceptance of donors with hypertension.
  • The long-term cardiovascular and renal safety for hypertensive living kidney donors remains uncertain.

Purpose of the Study:

  • To systematically review and synthesize existing literature on the safety of living kidney donation in hypertensive individuals.
  • To assess the cardiovascular and kidney health outcomes for living kidney donors with hypertension.

Main Methods:

  • A systematic review of prospective randomized, non-randomized, and retrospective studies.
  • Literature search of MEDLINE, EMBASE, Cochrane CENTRAL, and EBM reviews (1946-2021).
  • Assessment of donor survival, major adverse cardiovascular events, estimated glomerular filtration rate, and end-stage kidney failure.

Main Results:

  • Data extraction and study screening by two independent reviewers.
  • Risk of Bias in Non-Randomised studies tool will be used for bias assessment.
  • Meta-analysis will be performed on eligible studies.

Conclusions:

  • Findings will be disseminated in a peer-reviewed, open-access journal.
  • Results will inform clinical guidelines for evaluating and following up living kidney donor candidates.
  • This review addresses critical knowledge gaps in living kidney donation practices.
Abstract

Keywords:
HypertensionNephrologyRenal transplantation

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