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Updated: Aug 17, 2025

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Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
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Chronic Hypertrophic Herpes Simplex Infection: A 13-Year Delay
Angelina Farias Maia1, Aldejane Gurgel Rodrigues1, Ayane Cristine Alves Sarmento2
1Department of Obstetrics and Gynaecology, Federal University of Pernambuco, Recife, Brazil.
Journal of Lower Genital Tract Disease
|December 15, 2022
Summary
Hypertrophic herpes is a rare condition that is frequently misdiagnosed, leading to a significant decline in patients' quality of life. Early detection and proper management are crucial for improving patient outcomes.
Area of Science:
- Medical Diagnostics
- Dermatology
- Virology
Background:
- Hypertrophic herpes is an uncommon manifestation of herpes simplex virus infection.
- It is often overlooked or misdiagnosed due to its atypical presentation.
- The condition can lead to substantial impairment in a patient's quality of life.
Purpose of the Study:
- To highlight the diagnostic challenges associated with hypertrophic herpes.
- To emphasize the impact of this condition on patient well-being.
- To advocate for increased awareness and timely diagnosis.
Main Methods:
- Literature review of existing cases and diagnostic criteria.
- Analysis of clinical presentations and patient-reported outcomes.
- Comparison with differential diagnoses.
Main Results:
- Hypertrophic herpes presents with unique cutaneous findings distinct from typical herpes lesions.
- Delayed diagnosis is common, contributing to prolonged suffering.
- Quality of life is significantly diminished due to persistent symptoms and psychosocial distress.
Conclusions:
- Hypertrophic herpes requires heightened clinical suspicion for accurate and prompt diagnosis.
- Effective management strategies are essential to alleviate symptoms and improve quality of life.
- Further research is needed to understand the pathophysiology and optimize treatment protocols.

