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Dynamic Contrast-Enhanced MRI Parameters and Normalized ADC Values Could Aid Differentiation of Skull Base
A Baba1,2, R Kurokawa3, M Kurokawa3
1From the Division of Neuroradiology (A.B., R.K., M.K., Y.O., A.S.), Department of Radiology, University of Michigan, Ann Arbor, Michigan akirababa0120@gmail.com.
Background And Purpose:
The skull base osteomyelitis sometimes can be difficult to distinguish from nasopharyngeal cancer. This study aimed to investigate the differences between skull base osteomyelitis and nasopharyngeal cancer using dynamic contrast-enhanced MR imaging and normalized ADC values.
Materials And Methods:
This study included 8 and 12 patients with skull base osteomyelitis and nasopharyngeal cancer, respectively, who underwent dynamic contrast-enhanced MR imaging and DWI before primary treatment. Quantitative dynamic contrast-enhanced MR imaging parameters and ADC values of the ROIs were analyzed. Normalized ADC parameters were calculated by dividing the ROIs of the lesion by that of the spinal cord.
Results:
The rate transfer constant between extravascular extracellular space and blood plasma per minute (Kep) was significantly lower in patients with skull base osteomyelitis than in those with nasopharyngeal cancer (median, 0.43 versus 0.57; P = .04). The optimal cutoff value of Kep was 0.48 (area under the curve, 0.78; 95% CI, 0.55-1). The normalized mean ADC was significantly higher in patients with skull base osteomyelitis than in those with nasopharyngeal cancer (median, 1.90 versus 0.87; P < .001). The cutoff value of normalized mean ADC was 1.55 (area under the curve, 0.96; 95% CI, 0.87-1). The area under the curve of the combination of dynamic contrast-enhanced MR imaging parameters (Kep and extravascular extracellular space volume per unit tissue volume) was 0.89 (95% CI, 0.73-1), and the area under the curve of the combination of dynamic contrast-enhanced MR imaging parameters and normalized mean ADC value was 0.98 (95% CI, 0.93-1).
Conclusions:
Quantitative dynamic contrast-enhanced MR imaging parameters and normalized ADC values may be useful in differentiating skull base osteomyelitis and nasopharyngeal cancer. The combination of dynamic contrast-enhanced MR imaging parameters and normalized ADC values outperformed each measure in isolation.
Insights
Dynamic contrast-enhanced MRI and normalized ADC values can help differentiate skull base osteomyelitis from nasopharyngeal cancer. Combining these MRI techniques offers superior diagnostic accuracy for distinguishing these conditions.
Area of Science:
- Radiology
- Oncology
- Infectious Diseases
Background:
- Skull base osteomyelitis and nasopharyngeal cancer share similar imaging features, complicating diagnosis.
- Accurate differentiation is crucial for appropriate patient management and treatment.
Purpose of the Study:
- To investigate the differences between skull base osteomyelitis and nasopharyngeal cancer using dynamic contrast-enhanced (DCE) MR imaging and normalized apparent diffusion coefficient (ADC) values.
- To evaluate the diagnostic performance of these quantitative MRI parameters in distinguishing the two conditions.
Main Methods:
- Retrospective analysis of 8 patients with skull base osteomyelitis and 12 with nasopharyngeal cancer.
- Acquisition of dynamic contrast-enhanced MR imaging and diffusion-weighted imaging (DWI) data before treatment.
- Quantitative analysis of DCE-MRI parameters (e.g., Kep) and normalized ADC values from regions of interest (ROIs).
Main Results:
- Kep was significantly lower in skull base osteomyelitis (0.43) compared to nasopharyngeal cancer (0.57) (P = .04).
- Normalized mean ADC was significantly higher in skull base osteomyelitis (1.90) than in nasopharyngeal cancer (0.87) (P < .001).
- Combined DCE-MRI parameters and normalized ADC values achieved the highest diagnostic accuracy (AUC = 0.98).
Conclusions:
- Quantitative DCE-MR imaging parameters and normalized ADC values show promise in differentiating skull base osteomyelitis from nasopharyngeal cancer.
- The combination of DCE-MRI parameters and normalized ADC values provides superior diagnostic performance compared to individual measures.
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