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Dentin regeneration based on tooth tissue engineering: A review.
Ehsaneh Azaryan1,2, Fariba Emadian Razavi3, Mohammad Yahya Hanafi-Bojd4,5
1Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Biotechnology Progress
|December 15, 2022
Summary
Tooth tissue engineering (TTE) offers a promising solution for regenerating natural tooth features lost to damage or disease. This approach utilizes dental stem cells, scaffolds, and growth factors for effective dentin regeneration.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Dental Research
Background:
- Tooth loss significantly impacts quality of life, with current prosthetics lacking natural tissue regeneration.
- Existing dental repair methods are insufficient for restoring natural tooth structure and function.
Purpose of the Study:
- To explore the potential of tooth tissue engineering (TTE) for dentin regeneration.
- To investigate stem/progenitor cell-based strategies for repairing damaged dentin.
Main Methods:
- Reviewing the biological structure of dentin and the process of dentinogenesis.
- Examining the key components for dentin regeneration: cell sources, growth factors (GFs), and scaffolds.
- Focusing on cell-based tissue engineering (TE) approaches using biodegradable scaffolds.
Main Results:
- Tissue engineering (TE) using dental stem/progenitor cells shows promise for regenerating dental tissues.
- Cell-based TE strategies are identified as a highly potential method for creating biological substitutes for dental tissues.
- The study highlights the critical roles of cells, scaffolds, and growth factors in dentin regeneration.
Conclusions:
- Tooth tissue engineering (TTE) presents a viable strategy for regenerating dentin and restoring natural tooth characteristics.
- Further research into cell sources, growth factors, and scaffolds is crucial for advancing dentin regeneration techniques.
- This study provides insights into developing bioengineered dental tissues to improve patient quality of life.
