Related Experiment Video
Updated: Aug 17, 2025

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
Published on: September 20, 2019
Muscle cramps and contractures: causes and treatment
Jildou N Dijkstra1, Eline Boon1, Nick Kruijt1
1Department of Neurology, Radboud Universiteit, Nijmegen, The Netherlands.
Muscle cramps are painful, involuntary muscle contractions. This review provides a practical approach to diagnosing and treating muscle cramps and contractures, exploring their causes and pathophysiology.
Area of Science:
- Neurology
- Physiology
- Clinical Medicine
Background:
- Muscle cramps are common, painful, involuntary muscle contractions.
- They can be physiological or linked to various acquired/inherited causes, rarely indicating serious neuromuscular disease.
- Contractures, a myogenic muscle shortening, can mimic cramps.
Purpose of the Study:
- To present a practical clinical approach to muscle cramps and contractures.
- To address key diagnostic and management questions faced by clinicians.
- To review the causes, pathophysiology, and treatment options for muscle cramps and contractures.
Main Methods:
- Literature review and clinical expertise synthesis.
- Discussion of diagnostic criteria for cramps versus contractures.
- Exploration of differential diagnoses and etiological factors.
Main Results:
- Muscle cramps are generally self-limiting and often benign.
- Distinguishing cramps from contractures is crucial for diagnosis.
- Symptomatic cramps and contractures require identification of underlying causes.
Conclusions:
- A systematic approach aids in differentiating cramps from contractures and identifying causes.
- Effective management involves addressing underlying etiologies and providing symptomatic relief.
- Further research into pathophysiology can refine treatment strategies for muscle cramps and contractures.
More Related Videos
Related Concept Videos
Skeletal Muscle Relaxants: Therapeutic Uses
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...
Classification of Skeletal Muscle Relaxants
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Muscle Contraction
Centrally Acting Muscle Relaxants: Therapeutic Uses
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...

