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Oxidative Stress-Mediated Programmed Cell Death: a Potential Therapy Target for Atherosclerosis
Yuwu Chen1,2, Xing Luo1,2, Biyi Xu1,2
1Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, People's Republic of China.
Cardiovascular Drugs and Therapy
|December 15, 2022
Summary
Programmed cell death (PCD) plays a role in atherosclerosis (AS). Oxidative stress (OS) mediates PCD, influencing AS progression and offering potential therapeutic targets.
Area of Science:
- Cardiovascular Biology
- Cellular Pathology
- Molecular Medicine
Background:
- Programmed cell death (PCD), encompassing apoptosis, pyroptosis, ferroptosis, and necroptosis, is genetically regulated and implicated in chronic cardiovascular diseases.
- Atherosclerosis (AS), a chronic inflammatory condition marked by lipid metabolism disruption, involves various PCD types in its pathological processes like lipid core expansion and leukocyte infiltration.
- Oxidative stress (OS), an imbalance between free radicals and antioxidants, is increasingly recognized for its role in mediating PCD through mechanisms such as oxidation and deubiquitination.
Purpose of the Study:
- To analyze the specific regulatory mechanisms of PCD mediated by OS.
- To elucidate the multifaceted effects of OS-mediated PCD on the entire pathological progression of AS.
- To identify potential therapeutic targets for AS by understanding the interplay between OS and PCD.
Main Methods:
- Literature review and analysis of existing research on PCD, OS, and AS.
- Examination of molecular mechanisms linking OS to different PCD pathways.
- Synthesis of evidence on how OS-mediated PCD influences AS initiation and advancement.
Main Results:
- PCD, influenced by OS, contributes significantly to various stages of AS pathogenesis.
- OS modulates PCD through distinct molecular pathways, impacting cellular events in AS.
- The interaction between OS and PCD presents multifaceted effects on AS development.
Conclusions:
- Clarifying the mechanisms of OS-mediated PCD is crucial for understanding AS.
- Targeting OS-mediated PCD pathways may offer novel therapeutic strategies for AS.
- Further research into these interactions can lead to effective treatments for cardiovascular diseases.
Keywords:
ApoptosisAtherosclerosisFerroptosisNecroptosisOxidative stressProgrammed cell deathPyroptosisMore Related Videos
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