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Do prior neurological comorbidities predict COVID-19 severity and death? A 25-month cross-sectional multicenter study

Mojtaba Sharafkhah1, Farah Moayedi2, Nozhan Alimi2

  • 1Department of Neurology and Psychiatry, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Acta Neurologica Belgica
|December 15, 2022
PubMed

Insights

Chronic neurological disorders (CNDs) significantly increase the risk of death and severity in COVID-19 patients. Early COVID-19 diagnosis is crucial for individuals with CNDs to improve outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 prognosis is worsened by comorbidities.
  • The impact of chronic neurological disorders (CNDs) on COVID-19 outcomes remains unclear.

Purpose of the Study:

  • To assess if CNDs predict in-hospital mortality or severity in COVID-19 patients.

Main Methods:

  • Cross-sectional study of 7370 hospitalized COVID-19 patients (Feb 2020-Mar 2022).
  • CND defined as neurological conditions causing permanent disability.
  • Multivariate Cox-regression analyzed in-hospital mortality and COVID-19 severity.

Main Results:

  • 1654 (22.4%) patients had CNDs, presenting with higher age and comorbidities.
  • ICU admission (59.7% vs 20.3%) and mortality (43.4% vs 12.8%) were significantly higher in CND patients.
  • CND independently predicted death (HR 1.198, p=0.003).

Conclusions:

  • Chronic neurological disorders independently predict mortality and severity in COVID-19.
  • Early COVID-19 diagnosis is recommended for patients with CNDs.
Abstract

Keywords:
Death rateNeurological complicationsPrognostic factorsSARS-CoV

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