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New benzofuran-imidazoles as antimycotic agents. II. In vitro studies
L Riviera1, M G Bellotti, V Pestellini
1Institute of Medical Microbiology, University of Milan, Italy.
Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|August 1, 1987
Abstract:
Ten new imidazole derivatives, benzofuran-imidazoles, were studied in vitro to establish their antimycotic activity against 70 fungal strains, in comparison with three known imidazoles and, for the dermatophytes only, griseofulvin. A very high inhibitory activity against dermatophytes was shown by five of the new substances. The other filamentous fungi and yeasts showed a more marked variation in their susceptibility. However a good sensitivity of some isolates of Candida albicans and other yeasts was seen.