Association of admission serum calcium level with left ventricular dysfunction in patients with acute coronary
Hong Wang1, Rongrong Wang2,3, Junping Tian3
1Department of Endocrinology, Aerospace Center Hospital, Beijing, China.
Insights
Lower serum calcium levels in acute coronary syndrome (ACS) patients correlate with higher B-type natriuretic peptide (BNP) and lower left ventricular ejection fraction (LVEF). Low calcium is an independent risk factor for elevated BNP in ACS.
Area of Science:
- Cardiology
- Biochemistry
Background:
- The interplay between serum calcium and cardiac function in acute coronary syndrome (ACS) remains under-investigated.
- Understanding these relationships is crucial for managing ACS patients.
Purpose of the Study:
- To examine the association between admission serum calcium levels and left ventricular dysfunction in patients diagnosed with ACS.
Main Methods:
- A cross-sectional study involving 658 ACS patients.
- Serum calcium, B-type natriuretic peptide (BNP), and left ventricular ejection fraction (LVEF) were measured upon admission.
- Statistical analysis, including multivariate logistic regression, was employed.
Main Results:
- Lower serum calcium quartiles were linked to elevated BNP and reduced LVEF (P < 0.05).
- Patients with LVEF ≤ 50% had significantly lower serum calcium and higher BNP (P < 0.05).
- Admission serum calcium showed a positive correlation with LVEF (P < 0.01) and a negative correlation with BNP (P < 0.01).
- Low serum calcium was an independent predictor of elevated BNP (adjusted OR: 0.720; P = 0.048).
Conclusions:
- In ACS patients, admission serum calcium is positively associated with LVEF and inversely with BNP.
- Lower serum calcium levels are identified as an independent risk factor for elevated BNP in the context of ACS.
Background:
The relationship between serum calcium and left ventricular function in patients with acute coronary syndrome (ACS) has not been explored. Our aim was to investigate the correlation of admission serum calcium with left ventricular dysfunction in ACS patients.
Methods:
In this cross-sectional study, 658 ACS patients who were admitted in the Department of Cardiovascular Disease from June 1st, 2019 to December 31st, 2019 were enrolled in the present study. Serum calcium and B-type natriuretic peptide (BNP) were measured at admission. Left ventricular ejection fraction (LVEF) was assessed using echocardiography. The correlation between admission serum calcium and left ventricular dysfunction was analyzed.
Results:
When stratified by serum calcium quartiles calculated from all patients, patients with lower serum calcium quartile showed a markedly higher BNP and lower LVEF (P < 0.05). Patients with LVEF ≤ 50% showed a significantly lower serum calcium and higher BNP compared to those with LVEF> 50% (P < 0.05). Admission serum calcium was positively correlated with LVEF (P < 0.01) but negatively correlated with BNP (P < 0.01). Multivariate logistic regression analysis showed that lower serum calcium (adjusted OR: 0.720, 95% CI: 0.519-0.997, P = 0.048) was independently associated with BNP ≥ 300 pg/ml in ACS patients. Using LVEF as a dependent variable, no significant correlation between low serum calcium and left ventricular systolic dysfunction was found in ACS patients.
Conclusions:
In patients with ACS, admission serum calcium was positively correlated with LVEF and negatively with BNP. Lower admission serum calcium was an independent risk factor for elevated BNP.
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