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Published on: February 10, 2013
The effect of dobutamine on ocular blood flow of healthy adults: A 3D pseudocontinuous aterial spin labelling study
Linkun Cai1, Haijun Niu1, Pengling Ren2
1School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Insights
Dobutamine significantly increased ocular blood flow (OBF) in healthy adults. This finding suggests dobutamine may be a potential therapeutic option for conditions involving ocular vascular ischemia.
Area of Science:
- Ophthalmology
- Cardiology
- Medical Imaging
Background:
- Ocular blood flow (OBF) is crucial for preventing and managing various eye diseases.
- Limited therapeutic strategies currently exist to enhance OBF.
Purpose of the Study:
- To evaluate the impact of dobutamine on OBF in healthy adults.
- To identify risk factors influencing OBF.
Main Methods:
- Utilized 3D pseudocontinuous arterial spin labelling (3D-pcASL) with 3.0T-MRI to measure OBF.
- Administered intravenous dobutamine to 43 healthy participants.
- Collected concurrent physiological data.
Main Results:
- OBF significantly increased post-dobutamine administration (22.43 ± 9.87 to 47.73 ± 14.02 ml/min/100g, p < 0.001).
- Age, heart rate, and systolic blood pressure were identified as significant risk factors for OBF.
Conclusions:
- This is the first study to demonstrate dobutamine's effect on OBF.
- Intravenous dobutamine effectively increases OBF, presenting a potential future treatment for ocular vascular ischemia.
Abstract:
Purpose: Ocular blood flow (OBF) is an important risk factor for incidence, prevalence and progression of some ocular disorders. To date, there are very limited therapeutic options to increase OBF. This study investigated the effect of dobutamine on OBF of heathy adults using 3D pseudocontinuous arterial spin labelling (3D-pcASL), and explored the risk factors associated with OBF. Methods: Forty-three healthy participants (86 eyes) were given an intravenous injection of dobutamine. We measured OBF using 3D-pcASL with a 3.0T- MRI scanner, OBF values were independently obtained by two doctors from the OBF map. We also collected physiological parameters using a vital signs monitor. The OBF and physiological parameters in the in the period before and after dobutamine injection states were obtained. Results: OBF increased significantly after dobutamine injection using paired t test method (from 22.43 ± 9.87 to 47.73 ± 14.02 ml/min/100g, p < 0.001). Age, heart rate and systolic blood pressure were the main risk factors affecting OBF using logistic regression analysis (all p values < 0.05). Conclusion: To the best of our knowledge, this is the first study observing the effect of dobutamine on OBF. Our findings indicated that intravenously injected dobutamine increased OBF, making it a possible option to counteract ocular vascular ischaemia in the future.
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