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Functional analysis of differently expressed ferroptosis-related genes in patients with mitral valve prolapse

Hui Xie1, Liushun Wang1, Yihu Tang1

  • 1Department of Cardiovascular Surgery, Nanjing Medical University First Affiliated Hospital, Nanjing, China.

Frontiers in Genetics
|December 16, 2022
PubMed

Insights

Mitral valve prolapse (MVP) pathogenesis involves ferroptosis-related genes and long non-coding RNAs (lncRNAs). Key genes CDKN2A, SLC1A4, and ATF3 identified as potential therapeutic targets for MVP.

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Disease Pathogenesis

Background:

  • Mitral valve prolapse (MVP) is a growing global health concern within valvular heart diseases.
  • Current understanding of MVP's etiology and pathogenesis remains limited.
  • The interplay between ferroptosis-related genes and long non-coding RNAs (lncRNAs) in MVP is largely unexplored.

Purpose of the Study:

  • To investigate the role of ferroptosis-related genes in the pathogenesis of mitral valve prolapse (MVP).
  • To identify potential therapeutic targets for MVP based on gene expression analysis.
  • To explore the regulatory network of ferroptosis-related genes and lncRNAs in MVP.

Main Methods:

  • Transcriptomic sequencing of blood samples from MVP patients and healthy controls.
  • Analysis of differentially expressed genes (DEGs) and differentially expressed lncRNAs (DElncRNAs).
  • Construction of a co-expression network and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.

Main Results:

  • Identification of core ferroptosis-related genes CDKN2A, SLC1A4, and ATF3 associated with MVP.
  • These core genes are central in a regulatory network modulated by numerous lncRNAs.
  • Enrichment analysis revealed involvement in the extracellular region and p53 signaling pathway.

Conclusions:

  • CDKN2A, SLC1A4, and ATF3 are implicated in the pathophysiological processes of MVP.
  • These genes represent promising therapeutic targets for mitral valve prolapse.
  • Understanding the lncRNA regulation of these genes offers new insights into MVP mechanisms.
Keywords:
ferroptosisgenelncRNAmitral value prolapsevalve disease

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