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Updated: Aug 17, 2025
Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study
Sawsan Al-Obaidly1,2, Husam Salama3, Tawa Olukade4
1Obstetrics and Gynecology Department, Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.
Insights
Intrahepatic cholestasis of pregnancy (ICP) affects 8 in 1000 births. While ICP increases labor induction and moderate preterm birth risks, maternal and neonatal outcomes remain favorable.
Area of Science:
- Obstetrics and Gynecology
- Hepatology
- Perinatal Medicine
Background:
- Intrahepatic cholestasis of pregnancy (ICP) is a significant liver disorder during pregnancy with variable global occurrence.
- Understanding ICP's impact on pregnancy and neonatal outcomes is crucial for clinical management.
Purpose of the Study:
- To compare the incidence of Intrahepatic cholestasis of pregnancy (ICP) and associated pregnancy outcomes against normal pregnancies.
- To analyze trends in ICP incidence and outcomes between 2011 and 2017.
Main Methods:
- Retrospective analysis of perinatal registry data from 2011 and 2017.
- Comparison of key maternal and neonatal outcomes including stillbirths, labor induction, preterm birth, and neonatal morbidity.
Main Results:
- ICP incidence was 8 per 1000 births, with higher rates observed in 2017 compared to 2011.
- Women with ICP had a nearly sixfold increased likelihood of labor induction and a higher incidence of moderate preterm births.
Conclusions:
- Intrahepatic cholestasis of pregnancy is associated with increased rates of labor induction and moderate preterm birth.
- Despite these risks, women with ICP experienced favorable maternal and neonatal outcomes.
Background:
Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls.
Methods:
We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death.
Results:
The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017.
Conclusion:
Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.
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