Development of clinical pathways to improve multidisciplinary care of high-risk pediatric oncology patients

Agnes Reschke1,2, Rebecca M Richards1,3, Stephanie M Smith1

  • 1Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States.

Frontiers in Oncology
|December 16, 2022
PubMed

Insights

Clinical pathways improve care for pediatric oncology patients with emergencies like hyperleukocytosis or anterior mediastinal mass. These evidence-based tools standardize management, aiming to reduce complications and improve outcomes.

Area of Science:

  • Pediatric Oncology
  • Clinical Medicine
  • Evidence-Based Practice

Background:

  • Clinical pathways are effective in pediatric hospital medicine but underutilized in pediatric oncology.
  • Pediatric oncology patients often present with oncologic emergencies requiring urgent, multidisciplinary care.
  • Few studies document clinical pathways for high-risk pediatric oncology populations.

Purpose of the Study:

  • To present two novel clinical pathways for pediatric oncology patients presenting with hyperleukocytosis or anterior mediastinal mass.
  • To provide a framework for immediate, multidisciplinary care of these high-risk patients.
  • To facilitate collaboration, expedite diagnosis, and streamline treatment initiation.

Main Methods:

  • Development of two clinical pathways using a multidisciplinary approach at a single institution.
  • Focus on patients with hyperleukocytosis or anterior mediastinal mass.
  • Application in initial management, often within the pediatric intensive care unit.

Main Results:

  • Established critical frameworks for immediate care of high-risk pediatric oncology patients.
  • Facilitated multidisciplinary collaboration and timely treatment initiation.
  • Aimed to standardize care for improved patient outcomes.

Conclusions:

  • Clinical pathways offer a standardized approach to managing oncologic emergencies in pediatric oncology.
  • Implementation can decrease morbidity and mortality in high-risk pediatric cancer patients.
  • Standardized care pathways hold potential for excellent patient outcomes.

Related Concept Videos

Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
613
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
67
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
1.0K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
413