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Updated: Aug 17, 2025

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Longitudinal Trajectories of Post-Stroke Depression Symptom Subgroups.

Sameer A Ashaie^1,2, Carter J Funkhouser^3,4, Roxana Jabbarinejad³

¹Think and Speak, Shirley Ryan AbilityLab, Chicago, IL, USA.

Neurorehabilitation and Neural Repair

|December 16, 2022

Summary

Post-stroke depression involves somatic symptoms and anhedonia, which influence each other over time. Identifying these interconnected symptoms early can aid in targeted interventions for stroke survivors.

Keywords:

cross-lagged depression longitudinal stroke

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Area of Science:

Neuroscience
Psychiatry
Rehabilitation Medicine

Background:

Post-stroke depression is common and debilitating.
Distinct depressive symptom dimensions may follow different trajectories.
Understanding these patterns is crucial for public health.

Purpose of the Study:

Examine within-person and between-person links between depressive symptom dimensions post-stroke.
Investigate associations across three time points in the year after hospital discharge.
Assess the influence of clinical variables like aphasia.

Main Methods:

Stroke survivors completed the CES-D scale at discharge, 3 months, and 12 months.
Analyzed somatic symptoms, anhedonia, and negative affect subscales.
Employed random intercept cross-lagged panel models to differentiate effects.

Main Results:

Found reciprocal within-person associations between somatic symptoms and anhedonia.
These links persisted from discharge to 3 months and 3 months to 12 months.
Negative affect was not associated with somatic symptoms or anhedonia.

Conclusions:

Reciprocal links suggest a potential "vicious cycle" between somatic symptoms and anhedonia.
These dimensions may serve as key indicators for risk and intervention targets.
Early and regular depression assessment during rehabilitation is recommended.