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The functional border zone in conscious dogs.

K P Gallagher1, R A Gerren, X H Ning

  • 1Department of Surgery (Thoracic Section), University of Michigan Medical School, Ann Arbor 48109.

Circulation
|October 1, 1987
PubMed
Summary
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This study defines the functional border zone in conscious dogs during coronary occlusion. Findings show a narrow border zone with mild dysfunction, similar to anesthetized models.

Area of Science:

  • Cardiovascular Physiology
  • Myocardial Ischemia Research
  • Surgical Instrumentation

Background:

  • Previous functional border zone studies used anesthetized, open-chest models.
  • Conscious animal models are crucial for understanding physiological responses to ischemia.

Purpose of the Study:

  • To characterize the functional border zone in conscious dogs during circumflex coronary occlusion.
  • To quantify the lateral extent and severity of systolic wall thickening impairment.

Main Methods:

  • Sonomicrometers were used to measure systolic wall thickening in 14 instrumented dogs.
  • Myocardial blood flow maps delineated the perfusion boundary.
  • Sigmoid curves modeled wall thickening impairment relative to distance from the perfusion boundary.

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Main Results:

  • The functional border zone was defined as the distance to 97.5% of the nonischemic asymptote.
  • Lateral extent was approximately 32 degrees at 10 minutes and 28 degrees at 3 hours post-occlusion.
  • Average systolic wall thickening within the functional border zone decreased significantly (p < .01) but remained mild.

Conclusions:

  • A narrow functional border zone exists in conscious dogs during coronary occlusion.
  • Findings align with previous studies in anesthetized models, suggesting limited impact of anesthesia on this parameter.
  • Severe dysfunction is localized near the perfusion boundary, with mild overall impairment within the functional border zone.