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Immunoglobulin D in cerebrospinal fluid.
T A Out1, E A Hische, H K van Walbeek
1Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands.
Summary
Measuring Immunoglobulin D (IgD) in cerebrospinal fluid offers new insights into neurological diseases. Elevated IgD levels suggest abnormal intrathecal synthesis, aiding in understanding central nervous system immune responses.
Area of Science:
- Neurology
- Immunology
- Clinical Chemistry
Background:
- Immunoglobulin D (IgD) is a less understood immunoglobulin isotype.
- Intrathecal synthesis of immunoglobulins can indicate central nervous system inflammation.
- Previous studies have primarily focused on IgG in neurological conditions.
Purpose of the Study:
- To investigate the diagnostic utility of Immunoglobulin D (IgD) in cerebrospinal fluid (CSF).
- To compare the IgD index with the IgG index in neurological disease patients.
- To explore the significance of intrathecal IgD synthesis in the central nervous system (CNS).
Main Methods:
- Radioimmunoassay was used to quantify IgD levels in paired CSF and serum samples.
- IgD and IgG indices were calculated for each patient.
- Patients with various neurological diseases were included in the study.
Main Results:
- An elevated IgD index was observed in 18 of 41 multiple sclerosis patients.
- Overall, 52 out of 122 patients exhibited an increased IgD index.
- Increased IgD index did not consistently correlate with an elevated IgG index.
Conclusions:
- Elevated IgD index in CSF suggests abnormal intrathecal synthesis of IgD.
- CSF IgD determination provides valuable supplementary information on CNS immunological activity.
- IgD analysis may enhance the understanding of immune responses in neurological disorders.