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Published on: July 7, 2023
Pain Widespreadedness, and Not Primary Pain Location, is Associated With Comorbid Symptoms in Children With Chronic
Emily Foxen-Craft1,2, Elizaveta Bourchtein1,2, Chelsea Kaplan2
1Department of Pediatrics.
Insights
Widespread pain in children is more informative than primary pain location for understanding pain-related symptoms. This finding helps advance precise treatment for pediatric chronic pain.
Area of Science:
- Pediatric Pain Management
- Clinical Psychology
- Rheumatology
Background:
- Pediatric chronic pain is complex and heterogeneous.
- Traditionally, pain is classified by primary location, but widespread pain is increasingly recognized.
- A direct comparison between these classification methods is lacking.
Purpose of the Study:
- To compare the informativeness of primary pain location versus pain widespreadedness in pediatric chronic pain.
- To identify which categorization method better predicts pain-related outcomes.
Main Methods:
- 223 youth (8-23 years) with chronic pain completed intake surveys.
- Primary pain locations were categorized (headache, abdominal, musculoskeletal).
- Widespread pain and other outcomes (pain interference, kinesiophobia, catastrophizing, anxiety, depression, sleep, fatigue) were assessed.
Main Results:
- Primary pain location was only associated with kinesiophobia.
- Pain widespreadedness was significantly associated with pain interference, catastrophizing, fatigue, anxiety, and depression, after controlling for covariates.
- Widespread pain demonstrated a more consistent association with multiple pain-related outcomes.
Conclusions:
- Pain widespreadedness is a more informative metric than primary pain location for pediatric chronic pain.
- Utilizing body maps to assess widespread pain may help identify nociplastic pain mechanisms.
- Improved assessment of pain mechanisms can lead to more precise treatment strategies for pediatric chronic pain.
Objectives:
Pediatric chronic pain represents heterogeneous diagnoses; often, primary pain location informs research classifications and treatment. In contrast, recent research has highlighted the role of widespread pain and this perspective has been adopted in assessments in specialty pediatric pain clinics. The lack of direct comparison between these 2 methods of categorizing pediatric chronic pain may hinder the adoption of evidence-based practices across the spectrum of care. Therefore, this study aimed to compare whether primary pain location or pain widespreadedness is more informative for pain-related symptoms in pediatric chronic pain.
Methods:
Youth (n=223) between the ages of 8 to 23 years (M=15.93, SD=2.11, 83% female) completed surveys upon intake at the pediatric chronic pain clinic. Free-text entries of primary pain location were coded into categories: headache, abdominal pain, and musculoskeletal pain. Additional domains assessed included widespread pain, pain interference, kinesiophobia, catastrophizing, anxiety, depression, sleep, and fatigue.
Results:
Differences based on primary pain location only emerged for kinesiophobia, F(2150)=8.20, P<0.001, with the highest scores among those with musculoskeletal pain. In contrast, controlling for sex, age, and pain intensity, pain widespreadedness was associated with pain interference, pain catastrophizing, fatigue, anxiety, and depression (P<0.05).
Discussion:
Pain widespreadedness was more consistently associated with pain-related outcomes among pediatric chronic pain patients than primary pain location, and body maps may be useful in determining a nociplastic pain mechanism to inform treatment. Improved assessment of pediatric pain mechanisms may help advance more precise treatment delivery.
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