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Nucleoside-Based Supramolecular Hydrogels: From Synthesis and Structural Properties to Biomedical and Tissue

Maria Godoy-Gallardo1, Maria Merino-Gómez1, Luisamaria C Matiz1

  • 1Bioengineering Institute of Technology (BIT), Department of Basic Science, International University of Catalonia (UIC), Carrer de Josep Trueta, 08195 Sant Cugat del Vallès, Barcelona, Spain.

ACS Biomaterials Science & Engineering
|December 16, 2022
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Summary

Nucleoside-based supramolecular hydrogels offer advanced biocompatibility and stimuli-responsive properties for tissue engineering and drug delivery. Recent improvements enhance their stability, printability, and bioactivity, enabling sophisticated 3D bioprinting applications.

Keywords:
enhancement of mechanical propertiesguanosine and derivativesnucleoside-based hydrogelsself-assemblystability improvementsupramolecular hydrogel

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Supramolecular Chemistry

Background:

  • Supramolecular hydrogels are vital for tissue scaffolding, diagnostics, and drug delivery due to biocompatibility and responsiveness.
  • Nucleosides are excellent building blocks for hydrogels due to their interactions and modifiability.

Purpose of the Study:

  • To summarize recent advancements in nucleoside-based supramolecular hydrogels.
  • To discuss their synthesis, properties, and applications in tissue engineering.
  • To provide future perspectives on their development.

Main Methods:

  • Review of recent literature on nucleoside-based supramolecular hydrogels.
  • Analysis of synthesis strategies and structural properties.
  • Evaluation of applications in drug delivery and 3D bioprinting.

Main Results:

  • Significant progress has been made in improving hydrogel stability, printability, functionality, and bioactivity.
  • Multi-gelator systems, cation incorporation (e.g., silver), and additives enhance hydrogel performance.
  • Nucleoside hydrogels are now viable bioinks for 3D printing cell-laden scaffolds.

Conclusions:

  • Nucleoside-based supramolecular hydrogels show great promise for biomedical applications, particularly in tissue engineering and drug delivery.
  • Ongoing developments focus on enhancing material properties and expanding their use in advanced 3D bioprinting.
  • Further research will drive innovation in creating sophisticated, functional biomaterials.