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Updated: Aug 17, 2025

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
Published on: December 20, 2014
Cell and Molecular Biology of Centrosome Structure and Function
1Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, USA. SchattenH@missouri.edu.
Abstract:
The centrosome field has seen enormous progress during the past few decades which spans the large areas of cell biology with new information on cell cycle controls and cellular health; immunology with centrosomes being essential for the formation of the immunological synapse; neurobiology with new insights into centrosome dysfunctions leading to disorders and disease; stem cell biology with fate-determining distribution of centrosomal material during asymmetric cell division; cancer biology with huge insights into the role of centrosomes in disease initiation, progression, and manifestation; reproductive biology with essential centrosome functions in oocytes, during fertilization and embryo development in which centrosome dysfunctions can be related back to abnormal centrosomal material in the meiotic spindle of oocytes; and several others that will be highlighted in the specific chapters of this book.
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