Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

4.1K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
4.1K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

3.0K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
3.0K
Interphase00:54

Interphase

176.1K
The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
176.1K
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

240.0K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
240.0K
The Cell Cycle Control System01:28

The Cell Cycle Control System

3.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.1K
What is the Cell Cycle?00:56

What is the Cell Cycle?

6.6K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice.

PloS one·2024
Same author

CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis.

Journal of genetics and genomics = Yi chuan xue bao·2024
Same author

Editorial: New perspectives from the new Editor-in-Chief of Journal of Molecular Histology.

Journal of molecular histology·2024
Same author

MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.

Histochemistry and cell biology·2024
Same author

The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target.

Advances in experimental medicine and biology·2024
Same author

The Impact of Mitochondria in Ovarian Cancer Cell Metabolism, Proliferation, and Metastasis.

Advances in experimental medicine and biology·2024
Same journal

Christopher Addison (1869-1951): Distinguished Anatomist and Politician.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Surgical Contributions to Anatomical Knowledge.

Advances in anatomy, embryology, and cell biology·2026
Same journal

The Rise and Tragic Fall of Charles Averill MRCS (1796-1830), Gentleman Surgeon of Cheltenham.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Richard Owen's Golgotha: Lancaster Castle and the Prisoner's Head that Rolled.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Labiaplasty: Mind the Gap-How the Female Genital Cosmetic Surgery Industry Has Exposed Gaps in Modern Medical Anatomy Education.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Trends Versus Transformative Tools Within Anatomy Education: The Case for Ultrasound.

Advances in anatomy, embryology, and cell biology·2026
See all related articles

Related Experiment Video

Updated: Aug 17, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.1K

The Centrosome Cycle within the Cell Cycle.

Heide Schatten1

  • 1Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, USA. SchattenH@missouri.edu.

Advances in Anatomy, Embryology, and Cell Biology
|December 16, 2022
PubMed
Summary
This summary is machine-generated.

Accurate cell division requires synchronized distribution of genetic and centrosomal materials. This coordination between the nucleus and centrosomes is vital for cell cycle control, especially during mitosis.

More Related Videos

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

15.4K
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.3K

Related Experiment Videos

Last Updated: Aug 17, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.1K
Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
09:39

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

15.4K
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.3K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cell division necessitates precise segregation of genetic and centrosomal material.
  • The nucleus and centrosomes engage in complex structural and functional interactions.
  • Coordination between nuclear events and centrosome behavior is crucial for cell cycle progression.

Purpose of the Study:

  • To highlight the critical importance of synchronized distribution of genetic and centrosomal materials during cell division.
  • To emphasize the role of nucleus-centrosome relationships in cellular communication and cell cycle regulation.
  • To underscore the significance of synchrony between centrosomes and nuclear events during the interphase-to-mitosis transition.

Main Methods:

  • This study is a review of existing literature.
  • Analysis of structural and molecular processes governing cell division.
  • Examination of nucleus-centrosome interactions and their impact on cell cycle control.

Main Results:

  • Synchronized distribution of genetic and centrosomal materials is essential for daughter cell viability.
  • Nucleus-centrosome structural and functional relationships are key mediators of cell cycle progression.
  • Precise timing and coordination between nuclear and centrosomal events are critical for successful mitosis.

Conclusions:

  • The coordinated interplay between the nucleus and centrosomes is fundamental for accurate cell division.
  • Disruptions in nucleus-centrosome synchrony can lead to cell cycle dysregulation.
  • Understanding these processes is vital for comprehending cellular health and disease.