Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

4.1K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
4.1K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

3.0K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
3.0K
Spindle Assembly02:50

Spindle Assembly

3.7K
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
3.7K
Meiosis II01:57

Meiosis II

183.8K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
183.8K
Meiosis I01:49

Meiosis I

194.0K
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
194.0K
The Mitotic Spindle02:27

The Mitotic Spindle

6.7K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice.

PloS one·2024
Same author

CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis.

Journal of genetics and genomics = Yi chuan xue bao·2024
Same author

Editorial: New perspectives from the new Editor-in-Chief of Journal of Molecular Histology.

Journal of molecular histology·2024
Same author

MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte.

Histochemistry and cell biology·2024
Same author

The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target.

Advances in experimental medicine and biology·2024
Same author

The Impact of Mitochondria in Ovarian Cancer Cell Metabolism, Proliferation, and Metastasis.

Advances in experimental medicine and biology·2024
Same journal

Christopher Addison (1869-1951): Distinguished Anatomist and Politician.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Surgical Contributions to Anatomical Knowledge.

Advances in anatomy, embryology, and cell biology·2026
Same journal

The Rise and Tragic Fall of Charles Averill MRCS (1796-1830), Gentleman Surgeon of Cheltenham.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Richard Owen's Golgotha: Lancaster Castle and the Prisoner's Head that Rolled.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Labiaplasty: Mind the Gap-How the Female Genital Cosmetic Surgery Industry Has Exposed Gaps in Modern Medical Anatomy Education.

Advances in anatomy, embryology, and cell biology·2026
Same journal

Trends Versus Transformative Tools Within Anatomy Education: The Case for Ultrasound.

Advances in anatomy, embryology, and cell biology·2026
See all related articles

Related Experiment Video

Updated: Aug 17, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.1K

Centrosomes in Reproduction.

Heide Schatten1

  • 1Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, USA. SchattenH@missouri.edu.

Advances in Anatomy, Embryology, and Cell Biology
|December 16, 2022
PubMed
Summary
This summary is machine-generated.

Centrosomes are crucial for reproduction, impacting meiosis, fertilization, and embryo development. Errors in centrosome function lead to infertility, developmental issues, and diseases like cancer.

More Related Videos

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
09:41

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

Published on: December 28, 2021

1.9K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

15.1K

Related Experiment Videos

Last Updated: Aug 17, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.1K
Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
09:41

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

Published on: December 28, 2021

1.9K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

15.1K

Area of Science:

  • Cell Biology
  • Reproductive Biology
  • Developmental Biology

Background:

  • Centrosomes play critical roles in cell division and organization.
  • Proper centrosome function is essential for successful reproduction and development.

Purpose of the Study:

  • To detail the vital functions of centrosomes in reproduction.
  • To highlight the consequences of centrosome dysfunction.

Main Methods:

  • Review of existing literature on centrosome biology.
  • Analysis of centrosome roles in meiosis, fertilization, and embryonic development.

Main Results:

  • Centrosomes are essential for meiosis, fertilization, cell division, and tissue formation.
  • Defects in centrosome organization cause errors in spindle formation and cell division.

Conclusions:

  • Centrosome integrity is fundamental for fertility and normal development.
  • Dysfunctional centrosomes are linked to infertility, developmental arrest, and cancer predisposition.