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RORγt-lineage APCs: The Aire apparent
James M Gardner1,2, Adrian Liston3
1Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
Science Immunology
|December 16, 2022
Summary
New research reveals novel populations of Aire-positive and RORγt-positive antigen-presenting cells. These cells play surprising roles in maintaining immune balance and interacting with microbes.
Area of Science:
- Immunology
- Cell Biology
Background:
- Antigen-presenting cells (APCs) are crucial for immune regulation.
- Aire and RORγt are transcription factors involved in immune cell differentiation.
Purpose of the Study:
- To identify and characterize new populations of Aire+ and RORγt+ APCs.
- To elucidate the roles of these novel APC subsets in immune homeostasis and host-microbe interactions.
Main Methods:
- Flow cytometry and single-cell RNA sequencing were employed.
- In vivo and in vitro assays were used to assess cellular functions.
Main Results:
- Discovery of unique Aire+ and RORγt+ APC subsets with distinct properties.
- Demonstration of their involvement in maintaining immune homeostasis.
- Evidence of their contribution to host-microbe interactions.
Conclusions:
- Aire+ and RORγt+ APCs represent a more diverse and functionally significant population than previously understood.
- These findings expand our knowledge of immune regulation and host defense mechanisms.
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