Shortcomings and areas for improvement in digital pathology image segmentation challenges

Digital pathology image analysis challenges have been organised regularly since 2010, often with events hosted at major conferences and results published in high-impact journals. These challenges mobilise a lot of energy from organisers, participants, and expert annotators (especially for image segmentation challenges). This study reviews image segmentation challenges in digital pathology and the top-ranked methods, with a particular focus on how reference annotations are generated and how the methods' predictions are evaluated. We found important shortcomings in the handling of inter-expert disagreement and the relevance of the evaluation process chosen. We also noted key problems with the quality control of various challenge elements that can lead to uncertainties in the published results. Our findings show the importance of greatly increasing transparency in the reporting of challenge results, and the need to make publicly available the evaluation codes, test set annotations and participants' predictions. The aim is to properly ensure the reproducibility and interpretation of the results and to increase the potential for exploitation of the substantial work done in these challenges.