Toward improving nitrogen use efficiency in rice: Utilization, coordination, and availability

Nitrogen (N) fertilizer drives crop productivity and underlies intensive agriculture, but overuse of fertilizers also causes detrimental effects to ecosystem. To cope with this challenge while meeting the ever-growing demand for food, it is critical and urgent to improve nitrogen use efficiency (NUE) of crops. To date, numerous efforts have been made in developing strategies for NUE improvement with different disciplines. Given the intricate and interconnected route of N for delivering its effect, it is necessary to comprehensively understand various procedures and their interplays in determining NUE. In this review, we expand the scope of NUE improvement, not only the N utilization by plants, but also the N coordination with other resources as well as the N availability in the soil, which represent the major dimensions in manipulating NUE. Moreover, both agronomic practices and genetic improvement in facilitating NUE are also included and discussed. Lastly, we provide our perspective in improving the NUE in the future, particularly highlighting the integration of various agronomic and genetic approaches for NUE improvement underlying the sustainable agriculture.