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The role of VCAM-1 in diabetic retinopathy: A systematic review and meta-analysis

Yinglei Xu1, Huabin Hou2, Lei Zhao3

  • 1Department of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China; Department of Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China.

Journal of Diabetes and Its Complications
|December 16, 2022
PubMed

Insights

Vascular cell adhesion molecule-1 (VCAM-1) is elevated in diabetic retinopathy (DR) patients, correlating with disease severity. This suggests VCAM-1 is a potential biomarker for detecting DR.

Area of Science:

  • Ophthalmology
  • Immunology
  • Molecular Biology

Background:

  • Vascular cell adhesion molecule-1 (VCAM-1) is implicated in inflammatory processes.
  • The specific role of VCAM-1 in diabetic retinopathy (DR) requires further elucidation.
  • A meta-analysis on VCAM-1 in DR is currently lacking.

Approach:

  • A systematic literature search was conducted to identify studies investigating VCAM-1 in DR.
  • A random effects model was employed for meta-analysis.
  • The estimated mean difference in VCAM-1 levels between DR and control groups was evaluated.

Key Points:

  • Twenty studies were included in the meta-analysis.
  • VCAM-1 levels were significantly higher in patients with DR compared to controls (SMD: 0.67, 95% CI: 0.34-1.01, P < 0.0001).
  • Subgroup analysis revealed correlations between VCAM-1 levels and sample size, DR type, methodology, and disease severity.

Conclusions:

  • Elevated VCAM-1 levels are characteristic of DR.
  • VCAM-1 levels are associated with the severity of diabetic retinopathy.
  • VCAM-1 shows potential as a diagnostic biomarker for DR.
Abstract

Keywords:
Diabetic retinopathyMeta-analysisVCAM-1

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