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Updated: Aug 17, 2025

Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes
Published on: February 22, 2017
Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates
1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Abstract:
Plaza-Jennings et al. applied single-nucleus RNA-seq, sorted neuronal and microglia cells for HiC, and found that chronic HIV infection in the brain induces interferon stimulation in microglia, drives chromatin reconfiguration into a transcriptionally active environment, and changes HIV integration landscape.
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