Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

31.0K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
31.0K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

177
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
177
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

2.3K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.3K
Synthesis of Phosphatidylcholine in the ER Membrane01:27

Synthesis of Phosphatidylcholine in the ER Membrane

3.2K
The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
3.2K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

2.5K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.5K
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

366
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
366

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use and implementation of prehabilitation in major abdominal surgery: Results of an international survey.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Clinical Characteristics at the Diagnosis of New Primary Melanoma in Italy: A Multicenter Retrospective Study Before and After the COVID-19 Pandemic.

Journal of clinical medicine·2026
Same author

Clinical outcomes of hypertriglyceridemia-associated acute pancreatitis: a prospective multicenter Italian cohort.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2026
Same author

Prehabilitation in oncological patients undergoing major gastrointestinal surgery: rationale and design of the PROGRESS trial.

Contemporary clinical trials·2026
Same author

The International Study Group for Pancreatic Surgery (ISGPS) Definition and Classification of Postpancreatectomy Mortality.

Annals of surgery·2026
Same author

Post-surgical diets in the ERAS protocol: D-ERAS scoping review.

European journal of clinical nutrition·2025

Related Experiment Video

Updated: Aug 17, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.6K

Pharmaconutrition: Which substrates?

Luca Gianotti1, Luca Nespoli1, Marta Sandini2

  • 1School of Medicine and Surgery, Milano-Bicocca University, Department of Surgery, IRCCS San Gerardo Hospital, Monza, Italy.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|December 16, 2022
PubMed
Summary
This summary is machine-generated.

Pharmaconutrition, using specific nutrients at high doses, can modulate immune pathways. Enteral immunonutrition formulas significantly reduce post-surgical infections and hospital stays.

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.1K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Related Experiment Videos

Last Updated: Aug 17, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.6K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.1K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Area of Science:

  • Nutritional Science
  • Immunology
  • Clinical Medicine

Background:

  • Pharmaconutrition and immunonutrition utilize specific nutritional substrates to modulate immune and inflammatory pathways.
  • Over-physiologic doses are required for these substrates to achieve therapeutic effects.
  • Single substrates like glutamine or omega-3 fatty acids have shown limited clinical benefits for postoperative complications.

Purpose of the Study:

  • To evaluate the efficacy of enteral immunonutrition (EIN) formulations in reducing post-surgical morbidity.
  • To assess the impact of multiple substrate formulas compared to control diets.
  • To explore contemporary applications of pharmaconutrition in enhanced recovery and prehabilitation settings.

Main Methods:

  • Systematic review and meta-analysis of randomized clinical trials.
  • Comparison of enteral multiple substrate formulas against control diets.
  • Focus on formulations combining arginine, omega-3 fatty acids, and ribonucleic acid, with or without glutamine.

Main Results:

  • Enteral multiple substrate formulas significantly reduced infectious complications.
  • A significant decrease in the duration of hospitalization was observed with EIN.
  • The most studied formulation involves arginine, omega-3 fatty acids, and ribonucleic acid.

Conclusions:

  • Enteral immunonutrition with multiple substrates is effective in reducing post-surgical complications and hospital stay.
  • Further research is needed to accurately test pharmaconutrition within enhanced recovery programs, neoadjuvant chemotherapy, and prehabilitation.
  • The precise modulation of immune and inflammatory pathways by specific nutritional substrates warrants continued investigation.