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Uncovering the genomic toll of the Black Death
Jonas Kuiper1, Peter van Endert2
1Department of Ophthalmology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands; Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Abstract:
The Black Death, a notorious devastating pandemic caused by Yersinia pestis infection during the 14th century, posed a formidable challenge to human immune defenses. A new article by Klunk et al. reports that a variant in an antigen-processing gene may have favored survival during the plague and may have undergone genomic selection in Europeans at unprecedented speed.
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