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Related Experiment Videos

Oral challenge with food additives.

N K Veien1, T Hattel, O Justesen

  • 1Dermatology Clinic, Aalborg, Denmark.

Contact Dermatitis
|August 1, 1987
PubMed
Summary

Food additives like preservatives and colorings did not show a significant link to eczema aggravation in a placebo-controlled study. Despite some reactions, oral challenges were not consistently reproducible, suggesting elimination diets may still be beneficial.

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Area of Science:

  • Dermatology
  • Clinical Immunology
  • Allergy

Background:

  • Eczema is a common skin condition often linked to environmental factors.
  • Patients frequently suspect food additives as triggers for dermatitis.
  • The role of specific food additives in eczema exacerbation requires clarification.

Purpose of the Study:

  • To investigate the effect of food additives on eczema.
  • To determine if oral challenges with food additives can reliably identify triggers.
  • To assess the correlation between additive reactions and specific food intolerances.

Main Methods:

  • A randomized, placebo-controlled oral challenge study was conducted.
  • 101 patients with eczema of undetermined origin participated.
  • Reactions to food additives (preservatives, colorings) and placebo were recorded.

Main Results:

  • 37 patients reacted to food additives, while 16 reacted to placebo.
  • No statistically significant difference was found between additive and placebo reactions.
  • Reactions were reproducible in only one-third of patients upon re-challenge.

Conclusions:

  • Oral challenges with food additives showed limited reliability in identifying eczema triggers.
  • Reactions to additives did not correlate with specific food intolerances.
  • An elimination diet may be warranted for suspected food additive intolerance, irrespective of challenge results.

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