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Transient receptor potential ion channels and cerebral stroke
Qin'yi Xu1, Yan Zou2, Zeng'li Miao1
1Department of Neurosurgery, The Affiliated Wuxi No. 2 Hospital of Nanjing Medical University, Wuxi, China.
Brain and Behavior
|December 17, 2022
Summary
Transient receptor potential (TRP) ion channels are implicated in stroke pathophysiology. Further research is needed to explore TRP channels as potential therapeutic targets for stroke patients.
Area of Science:
- Neuroscience
- Molecular Biology
- Pathophysiology
Background:
- Stroke is a major cause of death and disability globally, with increasing incidence in developing nations.
- Cerebral artery occlusion causes approximately 75% of strokes.
- Understanding stroke's impact on the brain is crucial.
Purpose of the Study:
- To review the role of transient receptor potential (TRP) ion channels in cerebral stroke.
- To explore the potential of TRP channels as therapeutic targets for stroke.
Main Methods:
- Literature search of PubMed and National Library of Medicine databases.
- Inclusion of all papers on cerebral stroke and TRP ion channels.
Main Results:
- TRP ion channels are calcium-permeable channels highly expressed in the brain.
- TRPC1/3/4/6, TRPV1/2/4, and TRPM2/4/7 channels have been linked to stroke pathophysiology.
- TRP channels facilitate calcium entry into cellular compartments.
Conclusions:
- The precise mechanisms of TRP ion channels in cerebral stroke remain unclear.
- TRP channels show potential as therapeutic targets for stroke.
- Further research is necessary to establish the efficacy of TRP channel-targeted therapies for stroke.
