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Updated: Aug 17, 2025

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
Published on: September 25, 2012
CNS tumor with BCOR internal tandem duplication
Lili-Naz Hazrati1,2, Maryam Monajemzadeh3, Zohreh Habibi4
1Department of Pathology, University of Toronto, University Health Network, Toronto, ON, Canada.
Abstract:
CNS tumor with BCOR internal tandem duplication is a recently proposed malignant tumor. The patient was an 18-month-old boy with torticollis and vomiting due to cerebellar hemispheric mass with extension to cerebellopontine angle and foramen magnum. Histopathologic examination of the tumor showed a moderately cellular tumor with microcystic formation, myxoid change, and atypical rosettes resembling Homer Wright rosettes. Illumina TruSight RNA Pan-Cancer NGS of the tumor genome revealed BCOR gene exon 15 internal tandem duplications.
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