Related Experiment Video
Updated: Aug 17, 2025
Studying Murine Small Bowel Mechanosensing of Luminal Particulates
Published on: March 18, 2022
Luminal mapping reveals mesenteric predominance of colonic adenomas and adenocarcinomas
Jim G Castellanos1, Sameer K Sharma2, Koiana Trencheva2
1Department of Anesthesiology, Weill Cornell Medicine/New York Presbyterian Hospital, 525 E 68th Street, New York, NY, 10065, USA.
Background:
Previous studies have examined the relationship between colorectal tumor distribution and metastasis, but the tumor luminal location and associative risk factors promoting tumor growth remain unknown.
Methods:
In this study, we mapped the luminal distribution of human colonic adenomas/adenocarcinomas and their association with various physiologic parameters.
Results:
We identified a mesenteric predominance for colonic adenomas and adenocarcinomas.
Conclusion:
The findings of this study raise the possibility of novel mechanistic pathways in the development of adenomas and subsequent transformation into adenocarcinomas.
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