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Related Experiment Video

Updated: Aug 17, 2025

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

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Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates with Asphyxia.

Tim Hermans¹, Katherine Carkeek^2,3,4, Anneleen Dereymaeker^2,3

¹Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Leuven, Belgium. tim.hermans@esat.kuleuven.be.

Advances in Experimental Medicine and Biology

|December 17, 2022

Summary

Neurovascular coupling (NVC) assessed by wavelet coherence effectively indicates hypoxic ischemic encephalopathy (HIE) severity in newborns. This brain monitoring technique shows potential for predicting neurodevelopmental outcomes after birth asphyxia.

Keywords:

Cerebral oxygenation Hypoxic-ischemic encephalopathy (HIE)NIRS Peripartal asphyxia Regional oxygen saturation (rSO2)

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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

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Published on: March 14, 2013

Area of Science:

Neonatal neurology
Biomedical engineering
Neuroscience

Background:

Brain monitoring is crucial for neonates with asphyxia to assess hypoxic-ischemic encephalopathy (HIE) severity and neurodevelopmental outcomes.
Neurovascular coupling (NVC), measuring the interaction between electroencephalography (EEG) and near-infrared spectroscopy (NIRS)-derived regional cerebral oxygen saturation (rSO2), is a potential biomarker for HIE.

Purpose of the Study:

To explore wavelet coherence for assessing NVC in neonates with HIE.
To compare EEG pre-processing methods (aEEG vs. EEG bandpower) for wavelet coherence computation.
To propose average real coherence as a novel NVC biomarker for HIE.

Main Methods:

Wavelet coherence was calculated for 18 neonates undergoing therapeutic hypothermia within the first 3 days of life.
EEG data were pre-processed using amplitude-integrated EEG (aEEG) and EEG bandpower methods.
Average real coherence was computed to quantify NVC between EEG bandpower and rSO2.

Main Results:

Wavelet coherence between EEG bandpower and rSO2 effectively differentiates HIE severity.
Average real coherence in the 0.21-0.83 mHz range correlated with HIE severity: high (positive) in mild, low (positive) in moderate, and negative in severe HIE.
NVC assessment using wavelet coherence shows promise as a biomarker for HIE in neonates with peripartal asphyxia.

Conclusions:

Neurovascular coupling, assessed via wavelet coherence of EEG bandpower and rSO2, is a valuable biomarker for HIE severity in neonates.
Further validation in larger patient cohorts is necessary to confirm these findings and clinical utility.